Resting-state frontostriatal functional connectivity in Parkinson's disease-related apathy.
Identifieur interne : 000076 ( Main/Exploration ); précédent : 000075; suivant : 000077Resting-state frontostriatal functional connectivity in Parkinson's disease-related apathy.
Auteurs : Hugo Cesar Baggio [Espagne] ; Bàrbara Segura ; Jose Luis Garrido-Millan ; Maria-José Marti ; Yaroslau Compta ; Francesc Valldeoriola ; Eduardo Tolosa ; Carme JunqueSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
Abstract
One of the most common neuropsychiatric symptoms in Parkinson's disease (PD) is apathy, affecting between 23% and 70% of patients and thought to be related to frontostriatal dopamine deficits. In the current study, we assessed functional resting-state frontostriatal connectivity and structural changes associated with the presence of apathy in a large sample of PD subjects and healthy controls, while controlling for the presence of comorbid depression and cognitive decline. Thirty-one healthy controls (HC) and 62 age-, sex-, and education-matched PD patients underwent resting-state functional magnetic resonance imaging (MRI). Apathy symptoms were evaluated with the Apathy Scale (AS). The 11 Beck Depression Inventory-II items that measure dysphoric mood symptoms as well as relevant neuropsychological scores were used as nuisance factors in connectivity analyses. Voxel-wise analyses of functional connectivity between frontal lobes (limbic, executive, rostral motor, and caudal motor regions), striata (limbic, executive, sensorimotor regions), and thalami were performed. Subcortical volumetry/shape analysis and fronto-subcortical voxel-based morphometry were performed to assess associated structural changes. Twenty-five PD patients were classified as apathetic (AS > 13). Apathetic PD patients showed functional connectivity reductions compared with HC and with non-apathetic patients, mainly in left-sided circuits, and predominantly involving limbic striatal and frontal territories. Similarly, severity of apathy negatively correlated with connectivity in these circuits. No significant effects were found in structural analyses. Our results indicate that the presence of apathy in PD is associated with functional connectivity reductions in frontostriatal circuits, predominating in the left hemisphere and mainly involving its limbic components.
DOI: 10.1002/mds.26137
PubMed: 25600482
Affiliations:
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Barcelona, Catalonia</wicri:regionArea><wicri:noRegion>Catalonia</wicri:noRegion></affiliation></author><author><name sortKey="Segura, Barbara" sort="Segura, Barbara" uniqKey="Segura B" first="Bàrbara" last="Segura">Bàrbara Segura</name></author><author><name sortKey="Garrido Millan, Jose Luis" sort="Garrido Millan, Jose Luis" uniqKey="Garrido Millan J" first="Jose Luis" last="Garrido-Millan">Jose Luis Garrido-Millan</name></author><author><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria-José" last="Marti">Maria-José Marti</name></author><author><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name></author><author><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></author><author><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name></author><author><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25600482</idno><idno type="pmid">25600482</idno><idno type="doi">10.1002/mds.26137</idno><idno type="wicri:Area/PubMed/Corpus">000286</idno><idno type="wicri:Area/PubMed/Curation">000286</idno><idno type="wicri:Area/PubMed/Checkpoint">000076</idno><idno type="wicri:Area/Ncbi/Merge">004223</idno><idno type="wicri:Area/Ncbi/Curation">004223</idno><idno type="wicri:Area/Ncbi/Checkpoint">004223</idno><idno type="wicri:Area/Main/Merge">000076</idno><idno type="wicri:Area/Main/Curation">000076</idno><idno type="wicri:Area/Main/Exploration">000076</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Resting-state frontostriatal functional connectivity in Parkinson's disease-related apathy.</title><author><name sortKey="Baggio, Hugo Cesar" sort="Baggio, Hugo Cesar" uniqKey="Baggio H" first="Hugo Cesar" last="Baggio">Hugo Cesar Baggio</name><affiliation wicri:level="1"><nlm:affiliation>Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona. Barcelona, Catalonia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departament de Psiquiatria i Psicobiologia Clínica, Universitat de Barcelona. 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In the current study, we assessed functional resting-state frontostriatal connectivity and structural changes associated with the presence of apathy in a large sample of PD subjects and healthy controls, while controlling for the presence of comorbid depression and cognitive decline. Thirty-one healthy controls (HC) and 62 age-, sex-, and education-matched PD patients underwent resting-state functional magnetic resonance imaging (MRI). Apathy symptoms were evaluated with the Apathy Scale (AS). The 11 Beck Depression Inventory-II items that measure dysphoric mood symptoms as well as relevant neuropsychological scores were used as nuisance factors in connectivity analyses. Voxel-wise analyses of functional connectivity between frontal lobes (limbic, executive, rostral motor, and caudal motor regions), striata (limbic, executive, sensorimotor regions), and thalami were performed. Subcortical volumetry/shape analysis and fronto-subcortical voxel-based morphometry were performed to assess associated structural changes. Twenty-five PD patients were classified as apathetic (AS > 13). Apathetic PD patients showed functional connectivity reductions compared with HC and with non-apathetic patients, mainly in left-sided circuits, and predominantly involving limbic striatal and frontal territories. Similarly, severity of apathy negatively correlated with connectivity in these circuits. No significant effects were found in structural analyses. Our results indicate that the presence of apathy in PD is associated with functional connectivity reductions in frontostriatal circuits, predominating in the left hemisphere and mainly involving its limbic components.</div></front></TEI><affiliations><list><country><li>Espagne</li></country></list><tree><noCountry><name sortKey="Compta, Yaroslau" sort="Compta, Yaroslau" uniqKey="Compta Y" first="Yaroslau" last="Compta">Yaroslau Compta</name><name sortKey="Garrido Millan, Jose Luis" sort="Garrido Millan, Jose Luis" uniqKey="Garrido Millan J" first="Jose Luis" last="Garrido-Millan">Jose Luis Garrido-Millan</name><name sortKey="Junque, Carme" sort="Junque, Carme" uniqKey="Junque C" first="Carme" last="Junque">Carme Junque</name><name sortKey="Marti, Maria Jose" sort="Marti, Maria Jose" uniqKey="Marti M" first="Maria-José" last="Marti">Maria-José Marti</name><name sortKey="Segura, Barbara" sort="Segura, Barbara" uniqKey="Segura B" first="Bàrbara" last="Segura">Bàrbara Segura</name><name sortKey="Tolosa, Eduardo" sort="Tolosa, Eduardo" uniqKey="Tolosa E" first="Eduardo" last="Tolosa">Eduardo Tolosa</name><name sortKey="Valldeoriola, Francesc" sort="Valldeoriola, Francesc" uniqKey="Valldeoriola F" first="Francesc" last="Valldeoriola">Francesc Valldeoriola</name></noCountry><country name="Espagne"><noRegion><name sortKey="Baggio, Hugo Cesar" sort="Baggio, Hugo Cesar" uniqKey="Baggio H" first="Hugo Cesar" last="Baggio">Hugo Cesar Baggio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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